A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries

A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries is described. The library preparation is simple, practical, and effective, generating compounds based around a known pharmacophore in high yield and purity. Furthermore, the procedure tolerates a diverse range of functionality in its substrates and is notable in allowing the preparation of compounds containing both free acids and bases without recourse to protection.