Author/Authors :
Yasuyuki Kawanishi، نويسنده , , Shoichi Ishihara، نويسنده , , Tadahiko Tsushima، نويسنده , , Kaoru Seno، نويسنده , , Masanori Miyagoshi، نويسنده , , Sanji Hagishita، نويسنده , , Michio Ishikawa، نويسنده , , Noriko Shima، نويسنده , , Mayumi Shimamura، نويسنده , , Yasunobu Ishihara، نويسنده ,
Abstract :
The chemical modification of the dual histamine H2 and gastrin receptor antagonists described in our preceding paper, particularly the modification of spacers as well as the alteration of their connecting bonds at the gastrin receptor antagonist site (GA) from the amide bond to the carbamate bond, significantly improved not only their dual activity but also the GA versus CCK-A receptor selectivity.
