Author/Authors :
David J. Blythin، نويسنده , , Shen-Chun Kuo، نويسنده , , Ho-Jane Shue، نويسنده , , Andrew T. McPhail، نويسنده , , Richard W. Chapman، نويسنده , , William Kreutner، نويسنده , , Charles Rizzo، نويسنده , , Hoyan S. She، نويسنده , , Robert West، نويسنده ,
Abstract :
The synthesis and GABAB antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X-ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration.
