Title of article
On the bioactive conformation of the gaba uptake inhibitor SK&F 89976-A
Author/Authors
T. G. Murali Dhar، نويسنده , , Hiroshi Nakanishi، نويسنده , , Laurence A. Borden، نويسنده , , Charles Gluchowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1535
To page
1540
Abstract
SK&F 89976-A (3) is a potent GABA uptake inhibitor, with a flexible diphenylbutenyl side chain. Conformationally restrained analogues of this compound, 14, 16, 18 and 20 were designed and synthesized to study the conformational preferences for binding to cloned GABA transporters. We conclude from this study that SK&F 89976-A probably binds to the GABA transporter in its fully extended conformation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788154
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