Author/Authors :
Vittorio Rasetti، نويسنده , , N. Claude Cohen، نويسنده , , Heinrich Rüeger، نويسنده , , Richard G?schke، نويسنده , , Jürgen Maibaum، نويسنده , , Frederic Cumin، نويسنده , , Walter Fuhrer، نويسنده , , Jeanette M. Wood، نويسنده ,
Abstract :
The design and synthesis of new truncated δ-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-peptide, lowmolecular weight renin inhibitors with improved pharmacokinetic properties.
