Title of article
Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11
Author/Authors
Brian A. McKittrick، نويسنده , , Andrew W. Stamford، نويسنده , , Xiaoyu Weng، نويسنده , , Ke Ma، نويسنده , , Samuel Chackalamannil، نويسنده , , Michael Czarniecki، نويسنده , , ReneéM. Cleven، نويسنده , , Ahmad B. Fawzi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1629
To page
1634
Abstract
We have synthesized a series of phosphinic acids as inhibitors of a metalloprotease endothelin converting enzyme (ECE). Potent ECE inhibitors 4g and 4o were identified. These compounds are members of a novel class of ECE inhibitors that are also potent inhibitors of angiotensin converting enzyme and neutral endopeptidase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788173
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