Synthesis and antimicrobial activity of 4-amino trinems

This article deals with the study carried out on the synthesis of 4-amino substituted trinems 1 starting from the key-intermediate (3S, 4R)-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1′R, 2′S, 3′R)-1′,2′-epoxycyclohex-3′-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and subsequent cyclization to the corresponding trinems were explored. Their synthesis and antimicrobial activity are reported.