Title of article
A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid
Author/Authors
Ho-Jane Shue، نويسنده , , Xiao Chen، نويسنده , , David J. Blythin، نويسنده , , Nicholas I. Carruthers، نويسنده , , James M. Spitler، نويسنده , , Shing-Chun Wong، نويسنده , , Richard W. Chapman، نويسنده , , Charles Rizzo، نويسنده , , Robert West، نويسنده , , Hoyan S. She، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1709
To page
1714
Abstract
A series of 3-amino-N-hydroxypropanesulfonamide analogs was prepared. Several compounds showed potent binding at the GABAB receptor and were active in an in vitro functional assay. The GABAB activity of these compounds appeared to be due to the fragmented product, 3-aminopropanesulfinic acid.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788188
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