Synthesis and technetium-99m labeling of cyclic GP IIb/IIIa receptor antagonists conjugated to 4,5-bis(mercaptoacetamido)-pentanoic acid (mapt)

The synthesis of cyclic Arg-Gly-Asp GP IIb/IIIa receptor antagonists conjugated to 4,5-bis(S-1-ethoxyethyl-mercaptoacetamido)pentanoic acid is reported. The corresponding Tc-99m-labeled complexes were prepared by exchange labeling with Tc-99m-glucoheptonate. This indirect labeling approach is an alternative to the preformed chelate approach using mapt.