Synthesis of furo[2,3-c]pyran-β-D-thymidine

A furo[2,3-c]pyran-β-D-thymidine nucleoside analog was synthesized from 5′-O-TBDMS-3′-C-allyl-thymidine by 4′-C-hydroxymethylation followed by an electrophilic 6-membered ring annellation. The new bicyclonucleoside was devoid of activity against HIV.