Synthesis, characterization, and anti-HIV activity of some 2-p-X-phenyl-1,3-N,N′-diphenyl-amidines

A series of six 2-p-X-phenyl-1,3-N,N′-diphenyl-amidines, in which X = H, Br, Cl, CH3, NO2 and OCH3 has been prepared and fully characterized by IR, 1H and 13C NMR, and GC-MS. Their anti-HIV activity and cytotoxicity varied greatly with different substitutions. The most active was the p-chloro compound, having a selectivity index of 125. All of the compounds with H, CH3 and OCH3 groups were essentially inactive.