Title of article
Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne
Author/Authors
Graham B. Jones، نويسنده , , Michael W. Kilgore، نويسنده , , Richard S. Pollenz، نويسنده , , Aiwen Li، نويسنده , , Jude E. Mathews، نويسنده , , Justin M. Wright، نويسنده , , Robert S. Huber، نويسنده , , Patricia L. Tate، نويسنده , , Thomas L. Price، نويسنده , , Robert P. Sticca، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1971
To page
1976
Abstract
An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788238
Link To Document