• Title of article

    Cyanoguanidine bioisosteres in potassium channel openers: Evaluation of 3,4-disubstituted-1,2,5-thiadiazole-1-oxides

  • Author/Authors

    Heinrich J. Schostarez، نويسنده , , Theresa J. OʹSullivan، نويسنده , , Vincent E. Groppi، نويسنده , , Loretta A. Cipkus-Dubray، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1996
  • Pages
    6
  • From page
    2187
  • To page
    2192
  • Abstract
    Bioisosteric substitution of the cyanoguanidine group found in pinacidil (1) with a 3,4-diamino-1,2,5-thiadiazole-1-oxide moiety and replacement of the 4-aminopyridine group with a 3,5-dichlorophenyl group has resulted in a new structural class of potassium channel opener (PCO).
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1996
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    788321