Asymmetric synthesis of enantiomerically pure (2S,1′S,2′S,3′R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors

The enantioselective synthesis of (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described.