Universal polymer support for the synthesis of 3′-end modified oligonucleotides

Functionalization of universal polymer supports is described for the synthesis of oligonucleotides bearing different functionalities (mercaptoalkyl or aminoalkyl) at 3′-end during final deprotection. Abstract A functionalization process for universal polymer supports is described for the synthesis of oligonucleotides bearing mercaptoalkyl or aminoalkyl at 3′-end during final deprotection.