• Title of article

    Inhibition of HSV-1 protease by benzoxazinones

  • Author/Authors

    Richard L. Jarvest، نويسنده , , Martin J. Parratt، نويسنده , , Christine M. Debouck، نويسنده , , Joselina G. Gorniak، نويسنده , , L. John Jennings، نويسنده , , Halina T. Serafinowska، نويسنده , , James E. Strickler، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1996
  • Pages
    4
  • From page
    2463
  • To page
    2466
  • Abstract
    Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC50 values. Formation of a monoadduct consistent with the acyl-enzyme complex was detected by mass spectroscopy. A parallel array synthesis was developed to explore 2-heteroatom substituted SAR.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1996
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    788377

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=788377