Author/Authors :
Ivan L. Pinto، نويسنده , , Andrew-West، نويسنده , , Christine M. Debouck، نويسنده , , Anthony G. DiLella، نويسنده , , Joselina G. Gorniak، نويسنده , , Kevin C. OʹDonnell، نويسنده , , Daniel J. OʹShannessy، نويسنده , , Arunbai Patel، نويسنده , , Richard L. Jarvest، نويسنده ,
Abstract :
A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyl oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases.
