Title of article
Mechanism-based inactivation of serine proteases by dichlorocyclopropane fused lactone derivatives
Author/Authors
Tsuyoshi Ohba، نويسنده , , Eitatsu Ikeda، نويسنده , , Naoki Tsuchiya، نويسنده , , Kuniko Nishimura، نويسنده , , Hisashi Takei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2629
To page
2634
Abstract
A dichlorocyclopropane fused lactone derivative was prepared as a novel mechanism-based inactivator of serine protease, α-chymotrypsin. The lactone derivative showed transient irreversible inhibitory activity toward α-chymotrypsin with the value of Kobsd/[I] = 54 M−1s−1 and the enzyme activity recovered perfectly after 6 hours.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788407
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