The synthesis of a hematoregulatory agent based on HP-5B containing an effective, achiral cystine replacement

The cystine moiety of the novel hematoregulatory peptide HP-5b has been substituted with an achiral N,N′-bis(carboxymethyl)-1,4-diaminobutane unit. The resulting compound was also a potent hematoregulatory agent, suggesting that N,N′-bis(carboxymethyl)-1,4-diaminobutane can function as an effective achiral cystine replacement in this molecular series.