A small library of peptidomimetics to systematically vary and test the effects of X1 constraints

A library of 47 peptidomimetics of YGGFLRFa was prepared wherein 32 of these contained 2,3-methanoleucine. This library was tested for binding the neuropeptide FF receptor where neuropeptide FF is FLFQPQRFa, an anti-opiate peptide. This study illustrates how conformational constraints can be systematically varied in a library forward to determine the best conformational restrictions for the desired activity.