Identification and biological activity of novel peptidomimetic gastrin/CCK-B receptor agonists

Identification and biological activity of novel peptidomimetic gastrin/CCK-B receptor agonists Original Research Article Pages 2971-2976 Graeme Semple, Hamish Ryder, David A. Kendrick, Andrzej R. Batt, Elizabeth Mathews, David P. Rooker, Michael Szelke, Akito Nishida, Keiji Miyata Close Close preview | Purchase PDF (310 K) | Related articles | Related reference work articles AbstractAbstract | ReferencesReferences Abstract The design, synthesis and biological activity of two novel series of compounds derived from the basic Boc-CCK-4 structure which provide potent ligands for the gastrin/CCK-B receptor is outlined. Within these series, new pseudopeptide compounds were discovered which unexpectedly were functional agonists in vivo, as shown by their ability to stimulate basal gastric acid secretion in rats, an effect which was blocked by the potent gastrin/CCK-B receptor antagonist YM022. Article Outline • References