Author/Authors :
Sajadi Tabassi، Sayyed Abolghassem نويسنده Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Movaffagh، Jebraeel نويسنده School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran , , Ghodsi، Ali نويسنده Targeted Drug Delivery Research Center, Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Fazly Bazzaz، Bibi Sedigheh نويسنده , , Ghodrati Azadi، Hamideh نويسنده Department of Basic Sciences, Fcaulty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, IR Iran ,
Abstract :
Background: Chitosan is a naturally occurring biopolymer which has been widely used in a variety of biomedical applications including
local antibiotic delivery due to its excellent mechanical properties, biodegradability and biocompatibility. Beads are spherical, porous carriers
which are prepared from various materials including chitosan. Objectives: The current study aimed to fabricate a new controlled delivery system for local anti-infective treatment and to study its release
behavior. Materials and Methods: Twenty beads were prepared from 1% or 2% chitosan solutions and immersed in vancomycin (VM) or teicoplanin (TN)
solutions. The antibiotic release kinetics was determined by linear regression analysis supposing first order kinetics. Results: Immersion for 3 h resulted in significant increase in the total TN release that differed from 0.5 h of immersion, except for the 1% beads
immersed in VM. Increasing the chitosan concentration significantly increased the total release and antibiotic load of beads. The release of
TN was more delayed compared to that of VM, which allowed a gradual release beyond 3 days. The half-life (mean ± SEM) of both types of TNcontaining
beads was significantly extended for 3 h immersion in comparison to 0.5 h immersion (26.1 ± 5.9 vs 10.9 ± 1.0 and 17.0 ± 2.1 vs 5.1 ±
1.9; P < 0.001). However, neither increasing the chitosan concentration, nor immersion time did result in any significant increase in the release
of VM. Conclusions: The current study demonstrated an improved control of TN release impregnated in beads. It can be concluded that chitosan
beads might be considered as a novel carrier for TN delivery to infected bone for local anti-infective therapy.