Author/Authors :
Helmut Schmidhammer، نويسنده , , Dietmar Daurer، نويسنده , , Martina Wieser، نويسنده , , Krisztina Monory and، نويسنده , , Anna Borsodi، نويسنده , , Jackie Elliott and، نويسنده , , John R. Traynor، نويسنده ,
Abstract :
The 5-methyl and 14-ethoxy substituted analogues (compounds 2 – 4) of the δ opioid receptor antagonist naltrindole showed similar selectivity when compared with the reference drug. Compound 2 was a δ receptor antagonist in the mouse vas deferens preparation (MVD) exhibiting considerably higher selectivity ratios than naltrindole, while compound 4 was found to be a full and potent δ receptor agonist in the MVD.
