Author/Authors :
Takeo Harada، نويسنده , , Jun Katada، نويسنده , , Akira Tachiki، نويسنده , , Tohru Asari، نويسنده , , Kiyoko Iijima، نويسنده , , Isao Uno، نويسنده , , Iwao Ojima، نويسنده , , Yoshio Hayashi، نويسنده ,
Abstract :
The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.
