Title of article
Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique
Author/Authors
Takeo Harada، نويسنده , , Jun Katada، نويسنده , , Akira Tachiki، نويسنده , , Tohru Asari، نويسنده , , Kiyoko Iijima، نويسنده , , Isao Uno، نويسنده , , Iwao Ojima، نويسنده , , Yoshio Hayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
209
To page
212
Abstract
The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788539
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