Title of article
New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases
Author/Authors
Brigitte Lesur، نويسنده , , Jean-Bernard Ducep، نويسنده , , Marie-Noelle Lalloz، نويسنده , , Anne Ehrhard، نويسنده , , Charles Danzin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
355
To page
360
Abstract
New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (Ki, t1/2) for inhibition of rat intestinal α-glucohydrolases as well as human lysosomal α-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal α-glucohydrolases.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788568
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