Author/Authors :
David L. Brown، نويسنده , , Balekudru Devadas، نويسنده , , Hwang-Fun Lu، نويسنده , , Srinivasan Nagarajan، نويسنده , , Mark E. Zupec، نويسنده , , Sandra K. Freeman، نويسنده , , Charles A. McWherter، نويسنده , , Daniel P. Getman، نويسنده , , James A. Sikorski، نويسنده ,
Abstract :
A survey of potential cyclic and acyclic lysine replacements in known -seryl- -lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good selectivity over the human enzyme. All of the heterocyclic lysine mimetics that were examined exhibited dramatically weaker affinity with the fungal enzyme
