Title of article :
Synthesis and structural optimization of 7-(3,3-disubstituted-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids as antibacterial agents
Author/Authors :
Hiroyuki Kitani، نويسنده , , Tsuyoshi Kuroda، نويسنده , , Akihiko Moriguchi، نويسنده , , Hideki Ao، نويسنده , , Fumihiro Hirayama، نويسنده , , Yoshifumi Ikeda، نويسنده , , Takeshi Kawakita، نويسنده ,
Abstract :
A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because of being most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability.
