Title of article
Characterization of cyclic ADP-ribose and 2′-phospho-cyclic-ADP-ribose by 31P NMR spectroscopy
Author/Authors
Klaus D. Schnackerz، نويسنده , , Chinh Q. Vu، نويسنده , , David Gani، نويسنده , , Rafael Alvarez-Gonzalez، نويسنده , , Myron K. Jacobson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
581
To page
586
Abstract
The 31P NMR spectra of the Ca2+ mobilizing nucleotides cyclic ADP-ribose and 2′-phosphocyclic ADP-ribose have been studied. Both nucleotides show doublets of doublets in the range −9.5 to −11 ppm for the pyrophosphate group. The P-cADPR exhibits a singlet in the 0 to +4 ppm range for the 2′-phospho group. The pH dependence of the 31P signals shows transitions with pKa values of 8.37 and 8.95 for cADPR and P-cADPR, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788613
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