Sulfonopeptide inhibitors of leukocyte adhesion

The amino acid sequence L-D-T-S-L has been shown to be a significant recognition motif involved in the interaction of integrin α4β7 with its endothelial ligand, MAdCAM-1. Based on the known active peptide, a series of sulfonamide peptidomimetics was synthesized. Sulfonopeptide 2, Ac-L-ψD-V-NH2, was shown to inhibit leukocyte adhesion.