Author/Authors :
Susana Herrero، نويسنده , , M. Luisa Su?rez-Gea، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده , , Rosario Herranz، نويسنده , , Santiago Ballaz، نويسنده , , Ana Barber، نويسنده , , Ana Fortu?o، نويسنده , , Joaqu?n Del R?o، نويسنده ,
Abstract :
The synthesis, binding to CCK receptors, and in vitro functional activity of pseudopeptide CCK-4 analogues incorporating the (R) or (S) Ψ[CH(CN)NH] peptide bond surrogate at the NIe31-Asp32or or Trp30-NIe13 bonds are described. Z-TrpΨ[(S)CH(CN)NH]NIe-Asp-Phe-NH2 retained the high CCK-B receptor binding affinity of Boc-[NIe31]-CCK-4, and was a potent and selective CCK-B antagonist in the isolated guinea pig ileum.
