Author/Authors :
Peter C. Astles، نويسنده , , Thomas J. Brown، نويسنده , , Paul Cox، نويسنده , , Frank Halley، نويسنده , , Peter M. Lockey، نويسنده , , Clive McCarthy، نويسنده , , Iain M. McLay، نويسنده , , Tahir N. Majid، نويسنده , , Andrew D. Morley، نويسنده , , Barry Porter، نويسنده , , Andrew J. Ratcliffe، نويسنده , , Roger J. A. Walsh، نويسنده ,
Abstract :
A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50=30μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was shown to further elicit functional antagonism in a human neutrophil C5a stimulated respiratory burst assay.
