Title of article
N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B4 receptor antagonists
Author/Authors
Paul D. Greenspan، نويسنده , , Alan J. Main، نويسنده , , Shripad S. Bhagwat، نويسنده , , Lester I. Barsky، نويسنده , , Robert A. Doti، نويسنده , , Alan R. Engle، نويسنده , , Lisa M. Frey، نويسنده , , Huanghai Zhou، نويسنده , , Kenneth E. Lipson، نويسنده , , Michael H. Chin، نويسنده , , Robert H. Jackson، نويسنده , , Susan Uziel-Fusi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
949
To page
954
Abstract
A series of N-aryl cinnamides has been prepared and assayed for antagonism of the leukotriene B4 receptor. Several compounds in this series were found to be highly potent antagonists of the human neutrophil receptor, based on a whole cell binding assay, as well as a neutrophil aggregation assay. This series is unique among LTB4 antagonists, due to its high degree of rigidity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788684
Link To Document