Title of article :
Synthesis and inhibitory effects of bivalent sialyl lewis X analogs at preventing cell adhesion
Author/Authors :
Hiroshi Miyauchi، نويسنده , , Masatoshi Yuri، نويسنده , , Masashi Tanaka، نويسنده , , Nobuko Kawamura، نويسنده , , Masaji Hayashi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
Several sialyl Lewis X (SLeX) dimers attached to symmetric linkers, 1,3-di(ω-hydroxyalkyl)-benzene, 1,3-di(ω-hydroxyalkoxy)benzene, and 1,3-di(ω-hydroxyalkoxy)cyclohexane, were synthesized and evaluated for their inhibitory activity against adhesion of HL-60 cells to recombinant soluble E-selectin. The SLeX dimers showed 4 to 6-fold higher inhibitory activity than the corresponding monomers.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
