Title of article
3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor
Author/Authors
Roland E. Dolle، نويسنده , , Denton Hoyer، نويسنده , , James M. Rinker، نويسنده , , Tina Morgan Ross، نويسنده , , Stanley J. Schmidt، نويسنده , , Carla T. Helaszek، نويسنده , , Mark A. Ator، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1003
To page
1006
Abstract
The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a kobs/[I] = 355 M−1s−1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788695
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