Title of article
ECD peptides inhibit in vitro fertilization in mice
Author/Authors
Amy Pyluck، نويسنده , , Ruiyong Yuan، نويسنده , , Edward Galligan Jr.، نويسنده , , Paul Primakoff، نويسنده , , Diana G. Myles، نويسنده , , Nicole S. Sampson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1053
To page
1058
Abstract
Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the β-subunit of fertilin were synthesized and tested as inhibitors of sperm-egg fusion in in vitro mouse fertilization assays. At 500 μM concentrations, reduced ECD peptides inhibited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain are recognized by its receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788706
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