Title of article
Structure-based design of novel, dipeptide ligands targeting the pp60Src SH2 domain
Author/Authors
Aurash Shahripour، نويسنده , , Kimberly S. Para، نويسنده , , Mark S. Plummer، نويسنده , , Elizabeth A. Lunney، نويسنده , , Debra R. Holland، نويسنده , , John R. Rubin، نويسنده , , Christine Humblet، نويسنده , , James H. Fergus، نويسنده , , James S. Marks MD MPH، نويسنده , , Alan R. Saltiel، نويسنده , , Tomi K. Sawyer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1107
To page
1112
Abstract
Based on the X-ray structures of the pp60Src (Src) SH2 domain complexed with two high affinity phosphopeptide ligands (Glu-Pro-Gln-pTyr-Glu-Glu-Ile-Pro-Ile-Tyr-Leu, and Ac-pTyr-Glu- -Hcy-NH2; Hcy = homocyclohexylalanine), we report herein the design and structure-activity relationships of a series of novel dipeptide ligands targeting the Src SH2 domain.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788717
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