Title of article
Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase
Author/Authors
J. -P. Gotteland، نويسنده , , C. Dax، نويسنده , , S. Halazy ، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1153
To page
1156
Abstract
Aromatic azides derived from known inhibitors have been prepared as potential photoaffinity labels for mammalian squalene epoxidase. Three of them (compounds 5b, 5c and 6) were found to inhibit pig liver SE with submicromolar affinities and to block cholesterol biosynthesis in HepG2 cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788726
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