Title of article
COMPARISON OF SNAKE VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES AS MODELS OF TNF-α CONVERTING ENZYME
Author/Authors
Drew E. Van Dyk، نويسنده , , Petra Marchand، نويسنده , , Robert C. Bruckner، نويسنده , , Jay W. Fox، نويسنده , , Bruce D. Jaffee، نويسنده , , Paul L. Gunyuzlu، نويسنده , , Gary L. Davis، نويسنده , , Sherrill Nurnberg، نويسنده , , Maryanne Covington، نويسنده , , Carl P. Decicco، نويسنده , , James M. Trzaskos، نويسنده , , Ronald L. Magolda، نويسنده , , Robert A. Copeland، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1219
To page
1224
Abstract
The reprolysin ht-d was compared to several human MMPs for the ability to cleave a peptide substrate representing the processing site of human pro-TNF. The rank order of inhibitor potency for a series of hydroxamic acids was also compared among these enzymes and for inhibition of TNF release from human white blood cells. The results suggest that ht-d is a better model TNF convertase than are the human MMPs. © 1997 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788740
Link To Document