Modelisation, Synthesis and Anti-HIV activities of N,N,N′,N″,N -pentakistetraazamacrocycles salts derivatives

The syntheses and the anti-HIV activities of new N,N,N′,N″,N -pentakistetraazamacrocyles salts analogues are described. From computer modeling studies, it was found that zinc coordination capacity of these pentakis derivatives was larger than the one of the corresponding tetrakis analogues. This suggest that a metal chelation energy could be a criteria to design novel anti-HIV polyazamacrocyles. © 1997 Elsevier Science Ltd.