Author/Authors :
Yasushi Kohno، نويسنده , , Katsuya Awano، نويسنده , , Mitsutomo Miyashita، نويسنده , , Takayoshi Ishizaki، نويسنده , , Kazuhiko Kuriyama، نويسنده , , Yasuhiko Sakoe، نويسنده , , Shinji Kudoh، نويسنده , , Koji Saito، نويسنده , , Eisuke Kojima، نويسنده ,
Abstract :
A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. (S)-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6-quinolineacetic acid (IRA-378) exhibits the effect against both acute and chronic inflammations. It also has suppressive effects of bone destruction in adjuvant arthritis and Ca release from bones in vitro.
