Author/Authors :
Patrice Préville، نويسنده , , John X. He، نويسنده , , Micheline Tarazi، نويسنده , , M. Arshad Siddiqui، نويسنده , , Wayne L. Cody، نويسنده , , Annette M. Doherty، نويسنده ,
Abstract :
Inogatran is an effective and selective pseudopeptide inhibitor of thrombin that has been shown to be efficacious in a series of in vitro and in vivo models of thrombosis. Herein, we report an efficient and convergent chemical synthesis of Inogatran that is amenable to the preparation of multiple gram quantities.