Author/Authors :
Philip M. Sher، نويسنده , , Arvind Mathur، نويسنده , , Liesl G. Fisher، نويسنده , , Gang Wu، نويسنده , , Stephen Skwish، نويسنده , , Inge M. Michel، نويسنده , , Steven M. Seiler، نويسنده , , Kenneth E. J. Dickinson، نويسنده ,
Abstract :
Carboxyl and other negatively charged groups were found to be most effective at producing human β3 adrenergic receptor binding selectivity in 1 (BRL 37344) and related compounds. The sulfonic acid analog 7 (BMS-187413) is a novel and potent β3 adrenergic agonist that binds selectively, and thus has an in vitro profile that compares favorably with that of BRL 37344.
