Author/Authors :
Louis N. Jungheim، نويسنده , , Jeffrey D. Cohen، نويسنده , , Robert B. Johnson، نويسنده , , Elcira C. Villarreal، نويسنده , , Mark Wakulchik، نويسنده , , Richard J. Loncharich، نويسنده , , Q. May Wang، نويسنده ,
Abstract :
Homophthalimides 2a and 3a were found to be inhibitors of Rhinovirus 3C protease through a blind screening effort. SAR studies resulted in compound 3g, which exhibited improved enzyme inhibition, in addition to whole cell antiviral activity. Molecular modeling studies suggest a preferred enzyme/inhibitor interaction, and LC/MS experiments confirmed tight/covalent binding of 3g to the enzyme.
