Author/Authors :
Norikazu Ohtake، نويسنده , , Hideaki Imamura، نويسنده , , Hideo Kiyonaga، نويسنده , , Hideki Jona، نويسنده , , Masayuki Ogawa، نويسنده , , Shigemitsu Okada، نويسنده , , Aya Shimizu، نويسنده , , Minoru Moriya، نويسنده , , Hiroki Sato، نويسنده , , Yushin Tominaga، نويسنده , , Koji Yamada، نويسنده , , Masato Nakano، نويسنده , , Ryosuke Ushijima، نويسنده , , Susumu Nakagawa، نويسنده ,
Abstract :
A new series of carbapenems, in which disubstituted-aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA. Among them, 9e and 9i were found to exhibit good in vivo efficacy comparable to that of vancomycin, for mouse septicemia model with high-level MRSA.
