Title of article :
New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages
Author/Authors :
Tadashi Honda، نويسنده , , Heather J. Finlay، نويسنده , , Gordon W. Gribble، نويسنده , , Nanjoo Suh، نويسنده , , Michael B. Sporn، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
New derivatives of 3-oxoolean-1-en-28-oic acid and 3-oxours-1-en-28-oic acid were synthesized. Nine of them showed significant inhibitory activity against interferon-γ-induced nitric oxide production in mouse macrophages when assayed at the 1 μM level. 3,12-Dioxoolean-1,9-dien-28-oic acid (3) had the highest activity (IC50, 0.9 μM).
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
