Title of article
Prolyl endopeptidase inhibitors1: N-acyl derivatives of L-thioproline-pyrrolidine
Author/Authors
K?nai K?roly، نويسنده , , Erd S?ndor، نويسنده , , Sus?n Edit، نويسنده , , Fehér Mikl?s، نويسنده , , Sipos Judit، نويسنده , , Pod?nyi Benj?min، نويسنده , , Szappanos Andrea، نويسنده , , Hermecz Istv?n، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1701
To page
1704
Abstract
A series of N-acyl derivatives of thioproline-pyrrolidine was prepared conventionally and evaluated in vitro against rat brain prolyl endopeptidase (PEP). It is argued on the basis of pharmacophore plots that an optimum chain length exists as a result of increased population of pharmacophore space and decreased solubility on increasing the alkyl chain length.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788836
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