Author/Authors :
Barry G. Shearer، نويسنده , , Shuliang Lee، نويسنده , , Karl W. Franzmann، نويسنده , , Helen A. R. White، نويسنده , , Daniella C. J. Sanders، نويسنده , , Rachel J. Kiff، نويسنده , , Edward P. Garvey، نويسنده , , Eric S. Furfine، نويسنده ,
Abstract :
Conformationally restricted analogues of the endogenous NOS substrate -arginine and the arginine based NOS inhibitors NG-methyl- -arginine ( -NMA) and Nδ-iminoethyl- -ornithine ( -NIO) were synthesized for evaluation as inhibitors of human NOS. Incorporation of a phenyl ring into the C4---C5 backbone chain provided 2-aminophenylalanine analogues which retained potent NOS inhibition. Structurally related analogues of 3-aminophenylalanine were significantly weaker inhibitors.
