Title of article
Synthesis and activity of C2-substituted analogs of influenza neuraminidase inhibitor GS 4071
Author/Authors
Lijun Zhang، نويسنده , , Matthew A. Williams، نويسنده , , Dirk B. Mendel، نويسنده , , Paul A. Escarpe، نويسنده , , Choung U. Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1847
To page
1850
Abstract
The influence of C2-substitution of GS 4071 on the influenza neuraminidase inhibitory activity was investigated. The introduction of lipophilic substituents (chloro, methyl, and methylthio) at the C2 position resulted in a significant decrease of the activity. This result indicates that at the enzyme active site there is limited hydrophobic pocket for group at the C2 position of GS 4071.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788865
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