Author/Authors :
Yasuki Yamada، نويسنده , , Koji Ando، نويسنده , , Kazuya Komiyama، نويسنده , , Saizo Shibata، نويسنده , , Ikuro Nakamura، نويسنده , , Yoshiharu Hayashi، نويسنده , , Kiyoteru Ikegami، نويسنده , , Itsuo Uchida، نويسنده ,
Abstract :
A series of low molecular renin inhibitors (molecular weight *< 600) were prepared and their biological activities were evaluated. The inhibitors containing indole-2-carbonyl moieties at the P3 position and 2-amino-3,5-anti-diol fragment at the P1-P1′ position showed renin inhibitory activities with IC50 of 10−8 M order and good blood pressure lowering effects after oral administration to sodium-depleted marmosets.
