Title of article
The synthesis and evaluation of the major metabolites of mazapertine
Author/Authors
Allen B. Reitz، نويسنده , , Mark E. McDonnell، نويسنده , , Ellen W. Baxter، نويسنده , , Ellen E. Codd، نويسنده , , Wu-Nan Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1927
To page
1930
Abstract
Several of the key metabolites of mazapertine, a novel antipyschotic agent, were prepared in order to firmly establish their chemical structure and to obtain samples for biological testing. Hydroxymazapertine 3 was synthesized via a multi-step procedure starting from 5-fluoro-2-nitrophenol (8). Alcohol 4 was originally proposed for one of the major metabolites, but the confirmed structure after synthesis was isomer 20.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788880
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